Spectrum of abnormal haemoglobin variant by cation exchange HPLC (D-10) in suspected population of haemoglobinopathy

Abstract

Inherited hemoglobin disorders include a broad spectrum of conditions, from 
thalassemia to structurally altered hemoglobin variants (hemoglobinopathies). 
Globally, it is estimated that 5% of people carry a potentially harmful hemoglobin gene. 
In India, the incidence of thalassemia traits ranges from 3% to 17%, while sickle cell 
disease affects between 1% to 44% of the population.